Quick Hits

Some of my most painful clinical encounters have been with young persons with advanced colorectal cancer (CRC) in whom opportunities for early diagnosis or prevention were missed: the young woman with obstructing CRC in late pregnancy after 14 months of symptoms that were not evaluated because of lack of insurance and then reluctance to perform […]

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Over 240 million people in the world are chronically infected with hepatitis B virus (HBV). In many infected individuals, initial infection leads to clearance (defined as the loss of surface antigen [HBsAg]). Some HBsAg negative individuals remain HBV DNA positive (i.e., occult HBV) and others have HBV DNA in the liver but are serologically cleared. […]

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Up to 30 percent of patients treated for an initial Clostridium difficile infection (CDI) develop a recurrence within eight weeks of completing a course of anti-CDI therapy and the risk of further recurrence increases with each subsequent episode. Multiply recurrent CDI is a frustrating and debilitating condition that appears to be increasing at a rate […]

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When we think about the optimal approach to managing patients with eosinophilic esophagitis (EoE), an important question arises: what is the most meaningful endpoint for therapy in EoE — is it histologic remission, endoscopic improvement or symptomatic resolution? While there may be some controversy among investigators regarding which endpoint is most important, most will agree […]

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Much progress has been made since the first studies of pancreatic screening were published almost 20 years ago. We have a better understanding of the risk factors that define high-risk individuals, and we have begun to understand the benefits and risks of pancreatic screening using endoscopic ultrasound (EUS) and other imaging tests. However, we have […]

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As gastroenterologists, we are understandably concerned with cuts in reimbursement, time pressures on clinic visits and other financial metrics that may set us back. Such issues often guide physicians’ stances on health reform, and it is easy to feel overwhelmed. However, as the health care debate continues, we should also remember that we have a […]

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The four U.S. gastroenterology and hepatology societies have made history this year. For the first time, the presidents of AGA, AASLD, ACG and ASGE are women. To mark and celebrate this occasion, the four presidents shared their experience and advice on taking on a leadership position. Sheila E. Crowe MD, AGAF AGA President What motivated you […]

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Combination direct-acting antiviral (DAA) therapy of eight to 24 weeks for the treatment of chronic hepatitis C is highly effective. Current guidelines do not encourage treatment for less than 12 weeks. However, mounting evidence indicates that many patients can achieve sustained virologic response (SVR) with only eight weeks of treatment. Thus, treatment for shorter durations […]

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Acute alcoholic hepatitis is a clinical syndrome characterized by sudden onset of jaundice, malaise, anorexia and occasionally abdominal pain associated with fever, tachycardia, leukocytosis and other evidence of a systemic inflammatory response in an individual who has been drinking heavily within the preceding eight weeks. By definition, serum bilirubin is elevated with modest elevation in […]

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With the recent approvals of infliximab biosimilars, CT-P13 and SB2, and adalimumab biosimilar, ABP 501, by the U.S. FDA, the landscape of available anti-tumor necrosis factor (TNF) therapies for the treatment of inflammatory bowel disease (IBD) is changing right before our eyes. To understand the implications of this change, it is important to consider several […]