Plan B
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 Medical treatment options for patients with inflammatory bowel diseases (IBD) — Crohn’s disease and ulcerative colitis (UC) — have rapidly expanded with several different classes of medications now available. Traditionally, conventional therapy has consisted of mesalamine, steroids and immunomodulators, but in the era of biologic therapy, new options are available. However, variability remains in approaches […]

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Clinicians may have noticed that pouchitis is no longer a simple, antibioticresponsive disease. Over the years, we have seen a growing number of patients with chronic antibiotic-refractory pouchitis (CARP). While the Asian “carp” fish has invaded our rivers and lakes, the CARP disease has become a threat to the wellness and even survival of the […]

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The availability of highly efficacious and tolerable all-oral direct acting antiviral (DAA) regimens for the treatment of chronic hepatitis C virus (HCV) infection in 2014 was met with a mix of joy and relief among both HCV providers and chronically infected patients. Finally we could do away with the low cure rates and toxicities associated […]

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Chronic pancreatitis has a wide spectrum of symptoms and severity, making it difficult to diagnose. While the advent of numerous radiographic, endoscopic and functional testing has certainly advanced our ability to reliably diagnose chronic pancreatitis, it can, at times, complicate diagnosis in an age of unclear interpretation of results. Given that this condition is not […]

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In the daily practice of gastroenterology, early detection of gastric cancer is especially difficult because of the flat morphology, rapid submucosal invasion and relatively short duration (about 1.5 years) of an asymptomatic stage. This presents a small window for gastroenterologists to identify early gastric cancer.1 The cause of gastric cancer is now recognized as chronic […]

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Small intestinal bacterial overgrowth (SIBO) is a condition where bacteria are seen in excess in the small intestine.1 It is associated with numerous conditions, the foremost of which are listed in Table 1. The stomach and proximal small bowel normally contain few bacteria, and when present, this overabundance of organisms can be associated with bloating, […]

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My goals in this article are to give you my current recommendations on how you should risk stratify and treat patients with peptic ulcer bleeding (PUB) and other types of non-variceal upper GI hemorrhage (NVUGIH), based upon recent studies performed by me and my research group, the CURE Hemostasis Research Group. For more than four […]

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Nonalcoholic fatty liver disease (NAFLD) is currently considered one of the most common chronic liver diseases in the world. NAFLD is defined as the fatty infiltration of the liver without secondary causes such as alcohol, medication, genetic and viral factors. Liver biopsies of patients with NAFLD can range from simple steatosis, which is the presence […]

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The prevalence of hepatitis C (HCV) in dialysis patients is higher than that of the general population, ranging from 1.8 to 8 percent in developed countries, with much higher rates in the developing world. Its prevalence correlates with the number of patient-years on dialysis. HCVinfected patients on maintenance dialysis experience increased mortality compared to uninfected […]