The opinion magazine of the American Gastroenterological Association
A meaningful discussion on the relevance of proton pump inhibitor–responsive esophageal eosinophilia (PPI-REE) in 2018 should first consider this question: How did we ever end up with this cumbersome term? Well, it arose as an artifact of early confusion regarding the need to distinguish eosinophilic esophagitis (EoE) from gastroesophageal reflux disease (GERD). This confusion led […]
Making the diagnosis of eosinophilic esophagitis (EoE), a clinicopathologic disease, requires the integration of patient symptoms, histology and clinical data. As gastroenterologists, we are obliged to do the same when monitoring for a therapeutic response. Although there are several axes on which EoE treatments may be assessed, no single measure has been shown to be sufficient. Therefore, considering the subjective experience together […]
When we think about the optimal approach to managing patients with eosinophilic esophagitis (EoE), an important question arises: what is the most meaningful endpoint for therapy in EoE — is it histologic remission, endoscopic improvement or symptomatic resolution? While there may be some controversy among investigators regarding which endpoint is most important, most will agree […]
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