Inside AGA

AGA Research Foundation pilot research awards are an invaluable tool for investigators. They provide seed funding to explore promising new lines of research and generate preliminary data for larger grants. When Ans Pauwels, PhD, MPharmSc, received the 2016 AGA-Rome Foundation Pilot Award in Functional Gastrointestinal and Motility Disorders from the AGA Research Foundation, she was able to intensify her […]

Quick Hits

Endoscopic eradication therapy (EET) with a combined approach of resection and ablation is safe and effective. The evolution of endoscopic mucosal resection (EMR) for visible lesions followed by radiofrequency ablation (RFA) has become the gold standard for Barrett’s associated neoplasia. Despite the effectiveness of EET, recurrence of intestinal metaplasia (IM) after achieving complete eradication (CE-IM) […]

Quick Hits

I cannot think of many areas in medicine where there are more divergent opinions than in extraesophageal manifestations (EEMs) of gastroesophageal reflux disease (GERD). There are fervent believers and deniers, with frequent swings of the pendulum depending on the latest proposed mechanism and the tests used to support them. Furthermore, the long list of purported […]

Debates

Gastroesophageal reflux disease (GERD) testing has evolved ever since the initial introduction of the catheter-based pH test more than half a century ago. More accurate pH measurements and improved patient tolerability were achieved by reducing the catheter’s diameter and stiffness, and the catheter-based pH test has continued to improve over the years.1 Introduction of the […]

Debates

Prolonged pH or reflux monitoring is neither essential to the primary evaluation or treatment of patients with suspected gastroesophageal reflux disease (GERD) who respond to therapy nor needed for patients who have endoscopydocumented erosive esophagitis that responds to antisecretory therapy. The history, endoscopic findings and clinical response to therapy provide adequate support for the diagnosis of GERD in […]

Quick Hits

The first clinical descriptions of eosinophilic esophagitis (EoE) emerged over two decades ago. Subsequently, adults with food impaction or dysphagia or change to children with non-descriptive gastroesophageal reflux disease (GERD)–like symptoms are increasingly recognized as having something different than GERD. Soon thereafter, a whole set of distinct eosinophilic GI diseases (EGID) involving various segments of […]

Quick Hits

Cough is among the most common symptoms for which medical attention is sought. It represents 10 to 38 percent of outpatient practice visits1,2 totaling over 26 million medical visits in the U.S. annually, and has a point prevalence of 9 to 33 percent in U.S. and European populations3. Most cough results from viral upper respiratory infection […]

Quick Hits

For the last 55 years, anti-reflux surgery (Nissen or Toupet fundoplication) has had excellent outcomes, few side effects and commendable durability for a functional repair. The procedure is a true anti-reflux operation, increasing lower esophageal sphincter pressure and eliminating acid reflux in 90 percent of patients. Thirty-day mortality is less than 1 percent (and 0 […]